International Journal of Dentistry Research 2020; 5(2): 76-80 ; DOI:10.31254/dentistry.2020.5210
BMP2 expression on periodontal of wistar rats with stz - induced diabetes mellitus after giving diet extract fish oil
Hansen Kurniawan1 , Dian Damaiyanti2
1. Department of Periodontics, Faculty of Dentistry, Universitas Hang Tuah Surabaya - Indonesia
2. Department of Oral Biology, Faculty of Dentistry, Universitas Hang Tuah Surabaya - Indonesia
*Author to whom correspondence should be addressed.
Received: 2nd April, 2020 / Accepted: 29th June, 2020 / Published : 30th August, 2020
Background : Diabetes mellitus (DM) is one of the most common metabolic disorders of high blood sugar levels. Lemuru fish is a resource of pelagic fish that has important economic value. Lemuru fish oil in addition to Omega-3 fatty acids that have been known as anti-inflammatory agent. Objective: To determine the effect of dietary extract of lemuru fish oil on BMP2 levels on periodontal tissue of Wistar rats induced with diabetes mellitus. Materials and Methods: The experiments were conducted with the Post Test Group design. Thirty male Wistar Rats were divided into four groups. Control group, Wistar induced STZ, but not treated. The first group of Wistar induced STZ and given lemuru fish oil extract 4ml / KgBB. The second group, Wistar induced STZ and given lemuru fish oil extract 8ml / KgBB and third group, Wistar induced STZ and given lemuru fish oil extract 16ml / KgBB. Wistar sacrificed. Then examined BMP2 with immunohistochemical methods. All data experiments were analyzed with Mann whitney (p <0.05). Results: The results of this study showed that the control group compared to third group , it was found that in the control group and third group had significant differences. While in second group compared to third group, it was found that in second group and third group did not have significant differences. In first group compared with third group , it was found that in first groups and third group had significant differences. Similarly in second group compared with third group it was found that in second group and third group it was significant difference. From the statistical test it can be seen that in second group compared to third group there was no difference of effect. Conclusion: There was an effect of dietary extract of lemuru
fish oil on BMP2 on periodontal tissue of Wistar rats induced by diabetes mellitus.
BMP2, Wistar , STZ, Immunohistochemistry
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